Ogi correctly answers the $250,000 question. Courtesy of Valleycrest Productions.
Boston University's doctoral program in cognitive neuroscience prepares students for a career in brain modeling, robot design, or biomedical engineering—or for winning cash on the television quiz show Who Wants to Be A Millionaire?. Researchers in my department, Cognitive and Neural Systems (CNS), seek to understand the brain's mechanisms, including three cognitive systems that happen to be essential for a profitable performance on Millionaire: learning, memory, and decision-making. This summer—the start of my final year in the CNS Ph.D. program—I decided to apply my graduate skills to a decidedly practical purpose and auditioned for a turn in the show's perilous hot seat.
I went to New York, where I passed a multiple-choice audition test. Two weeks later, I received the call to appear on the syndicated version of Millionaire, hosted by the empathic and playful Meredith Vieira. To prepare, I focused first on memory techniques, the subject of my doctoral dissertation.
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The first technique I drew upon was priming. The priming of a memory occurs because of the peculiar "connectionist" neural dynamics of our cortex, where memories are distributed across many regions and neurons. If we can recall any fragment of a pattern, our brains tend to automatically fill in the rest. For example, hearing an old Madonna song may launch a cascade of linked memories: your high school prom where it was the theme song, your poorly tailored prom outfit, your forgotten prom date, the stinging embarrassment when you threw up in the limo.
Since the producers allow contestants unlimited time to work out answers (as long as they're not just stalling), I knew that I could employ the most basic of priming tactics: talking about the question, posing scenarios, throwing out wild speculations, even just babbling—trying to cajole my prefrontal neurons onto any cue that could trigger the buried neocortical circuits holding the key to the answer.
I used priming on my $16,000 question: "This past spring, which country first published inflammatory cartoons of the prophet Mohammed?" I did not know the answer. But I did know I had a long conversation with my friend Gena about the cartoons. So I chatted with Meredith about Gena. I tried to remember where we discussed the cartoons and the way Gena flutters his hands. As I pictured how he rolls his eyes to express disdain, Gena's remark popped into my mind: "What else would you expect from Denmark?"
I used priming even more explicitly on my $50,000 question: "Which of the following acronyms represents an organization that does not include the word 'Association?'" I quickly narrowed it down to ASPCA and NCAA. I was confident I knew what NCAA stood for, but the pressure of the hot seat caused my amygdala to rage and blaze, preventing me, in the moment, from being able to recall the final two words of the acronym. I tried priming the missing words of the acronym, reiterating "National Collegiate Uh Uh, National Collegiate Uh Uh," over and over until my synapses finally fired off the complete pattern: "National Collegiate Athletic Association."
"A, American Society for the Prevention of Cruelty to Animals, final answer."
Another cognitive process essential for winning on Millionaire is intuition, or more precisely, knowing how to make decisions based on intuition. What if you have a feeling about an answer? What should you do with your hunch? Folk wisdom holds that on standardized tests you should go with your first impulse. Research tends to support this idea: a first impulse is more often correct than a second, revised decision. But what if $250,000 is at stake? "More often correct" does not seem certain enough to serve as a basis for a decision. How can you evaluate the true likelihood of a hunch being accurate?

